Standard gas addition: a calibration method for handling temporal drifts of mass spectrometry-based sensors.

This work describes a new method for the correction of signal drift of a MS-based sensor by standard gas addition (SGA). It consists of introducing a gaseous He-Xe mixture continuously and independently of the carrier gas into the mass spectrometer source. To mimic the disturbances generated by periodical tuning of the mass detector, three series of adjustments were made to the main acquisition parameters. The influence of the SGA signal correction on the discriminating power of the data was evaluated from the analysis of three batches of cheeses by dynamic headspace coupled to mass spectrometry. SGA afforded a good correction of the main types of drift classically observed in mass spectrometry.